杀出猛鬼大楼是一部恐怖片，席德在好友離奇失蹤後，與名叫莎拉的女孩一起調查好友失蹤的大樓，卻意外釋放隱藏在這棟大樓之中的邪惡怨靈。對世界滿懷仇恨的怨靈，將帶領成群噬血活屍席捲人類世界，希德與莎拉為了生存，必須抄起斧頭拚死殺出一條血路，一場血肉橫飛的生存之戰一觸即發……
Sarah (Roxanne Pallett) has just moved into a block of flats to start a new life away from her abusive mother. There, she strikes up an unconventional friendship with squatter Sid (Jason Mewes). When Sid's friend Paul goes missing, he and Sarah unearth a series of strange deaths and disappearances. Watched by a malevolent spirit controlling the building's televisions and cameras, reality and fantasy merge as events are twisted into a sick movie on a TV set high in the block of flats. Sid and Sarah are thrown into a fight for survival when the vengeful ghost controlling a horde of zombies possesses Sarah's mother (Frances Ruffelle). Evil suddenly has a familiar face.
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