Hilary Swank stars as Mary and Brenda Blethyn stars as Martha, an American interior designer and British housewife who have little in common apart from the one thing they wish they didn't. When malaria strikes, the lives of these very different women change forever. They forge a deep friendship and embark on an epic journey of self-discovery to Africa, dedicating themselves to the cause of malaria prevention. Beginning to rebuild their lives, they show how ordinary people can make a difference and inspire positive change in the process. Enlisting the help of Mary's estranged father, a former politico, the two women beseech both the powers that be and ordinary people to get involved, realizing a shared responsibility to all the world's children. 玛丽（希拉里·斯万克 Hilary Swank 饰）自由喜欢冒险，这个爱好在她已为人母之后也没有半点的改变，带着小儿子乔治（卢克斯·哈内-贾丹 Lux Haney-Jardine 饰），玛丽来到了非洲探险，谁知道，年幼的乔治抵抗力不足，在那里患上了疟疾，不幸去世了。乔治的死击破了玛丽的心理防线，也让玛丽和丈夫皮特（弗兰克·格里罗 Frank Grillo 饰）的感情走到了摇摇欲坠的边缘。虽然一切都是意外，但玛丽始终无法摆脱是自己害死了乔治的这一想法。 和玛丽遭遇相似的还有一位名叫莫桑（布兰达·布莱斯 Brenda Blethyn 饰）的女子，她的儿子也因为疟疾而永远的离开了她。这不可磨灭的创伤指引这两个心碎的女人走到了一起，她们之间产生了前所未有的坚定的友情。
