A shy, obsessive comic book fan gets injected with an experimental serum of a lab that is studying how to give humans the abilities of spiders. At first he develops minor abilities such as increased strength, which allows him to fight local criminals and bullies, thus living out his dream of being a superhero, and impressing his attractive next-door neighbor. Things start to get more odd when he is able to shoot webs out of his abdomen. Then he loses control over the force with which he applies his increasingly deadly abilities, as well as his judgment to discern between criminals and jokesters. His dream becomes a nightmare when he starts growing large spider body parts, he's in constant pain, and he develops a nearly insatiable hunger. A detective with a traumatized wife begins investigating when bodies covered in cobwebs and spider venom start piling up. 昆丁（德文·古梅尔萨尔 Devon Gummersall 饰）是一个非常平凡的年轻人，同时亦是一个漫画迷。平日里，他在生化科技实验室上班，是那里警卫。每一天，昆丁都会沉浸在自己的想象之中，幻想某一日他将获得一些超能力，化身成为拯救世界的超级英雄。 某日，一帮穷凶极恶的劫匪袭击的实验室，昆丁最好的朋友在交火中不幸丧生，这让昆丁感到十分悲痛，他发誓要替朋友报仇，并且拟定了一个危险的计划。实验室正在研究一种由蜘蛛血提炼而来的药物，昆丁偷到了这种药物，并且将它注入了自己的血液之中。可怕的事情发生了，昆丁并没有变成强壮的蜘蛛侠，而是渐渐的成为了毛茸茸的大蜘蛛。
