Edina Monsoon and her best friend Patsy drive Eddie's sensible daughter, Saffron, up the wall with their constant drug abuse and outrageous selfishness. 兩位年介四十,花樣年華的時髦女士–雅典娜與柏絲,終日周旋於時裝、體重、人與酒精之間,爆笑的衣著及出位的異常行為,經常令人嘩然。偶然地,因工事出差到寫字樓去,過著「充實」的生活。可惜,人生總是充滿喜與怒、樂和哀,兩位阿姨也不例外。幸福的是,她倆的生活總比別人瘋狂、總是胡鬧、總是荒唐!