Ghosts of Mississippi is a real-life drama covering the final trial of Byron De La Beckwith, the assassin of heroic civil rights leader Medgar Evers. The movie begins with the murder on June 12, 1963 and the events surrounding the two initial trials which both ended in hung juries. The movie then covers district attorney Bobby De Laughter's transformation and alliance with Myrlie Evers, Medgar Evers' widow, as he becomes more involved with bringing Beckwith to trial for the third time 30 years later. Byron De La Beckwith was convicted on February 5, 1994, after having remained a free man for much of the 30 years after the murder, giving justice for Medgar Evers' family. 为一个魂灵而战。 1963年，密西西比州的民权运动领袖麦格艾维斯，在自家的车道上被谋杀，凶手是白人种族主义者布莱恩柏克伍斯，但是他却无罪释放，逍遥法外30年，正义在经过30年之后才出现一线曙光，这是否会太晚了呢？当年麦格被谋杀后，所以有力的证据都指出布莱恩是凶手，但是全由白人组成的陪审团二度无罪释放他。30年后，一位年轻的地方检察官巴比，决定重新审理这个看人以毫无胜算的案子，他在麦格遗孀玛丽艾维斯的帮助下，收集了足够的新证据后，对凶手进行第三次的起诉，最后终于使正义伸张。
